供biovendor Progranulin Human ELISA 欣博盛供
貨號:RMEE103R
名稱:Progranulin Human ELISA
規格:96 wells (1 kit)
產品描述:
progranulin也被稱為顆粒上皮前體,proepithin或acrogranin。它是一種68.5 kDa蛋白質,由593個氨基酸(包括信號肽)組成,在體內以強糖基化形式出現,因此其大小約為90 kDa。progranulin有七個保守域,由連接序列分離。通過蛋白水解酶分解,在絲氨酸蛋白酶(如彈性蛋白酶)的催化下,產生6-25kDa的大片段,稱為顆粒或上皮。progranulin尤其在腺樣體組織、脾臟、皮膚上皮、胃腸粘膜、造血細胞和腫瘤細胞等強增殖組織中表達和分泌。到目前為止,還沒有一種特定的受體能獲得前體蛋白或顆粒的作用。progranulin似乎是一個積極影響傷口愈合的因素。在皮膚損傷的情況下,在癌細胞、巨噬細胞和中性粒細胞中表達增加。progranulin通過激活巨噬細胞和刺激受損組織中的血管生成間接影響傷口愈合。前體蛋白和顆粒的生理作用是相反的。progranulin可抑制TNF介導的促炎過程。另一方面,顆粒似乎刺激促炎細胞因子的分泌。丙戊酸鈉對炎癥過程的影響也可在動脈硬化斑塊中表現出來。在這里,progranulin由平滑肌細胞表達,并影響單核細胞和平滑肌細胞的遷移。在netual系統中,progranulin在小膠質細胞和神經元中表達(在新皮層和海馬錐體細胞以及小腦的浦肯野細胞中)。在mRNA水平上,在netual系統infect或損傷時,如I型和IIib型粘多發性脊髓灰質炎、netual系統virus性炎癥、肌萎縮性側索硬化和阿爾茨海默氏癥時,可顯示出明顯的前體蛋白表達增加。除此之外,progranulin似乎與出生前和出生后性別特異性差異的發展以及成人的神經可塑性有關。
特點:
It is suited for Progranulin determination in Serum and Plasma samples
It is extremely sensitive (18 pg/ml) and, thus allows measurements in cell culture media too and in specimens others than serum e.g. in Cerebrospinal fluid, Amnion fluid, Saliva, Urine, Breast milk - is fast: incubation time a total of 2 hours
Single Standards with 75, 250, 750, 1500, 2500 pg/ml human Progranulin are provided in the Kit
2 Control Sera are provided for quality control purposes according GLP
It is calibrated with recombinant Progranulin
Microtiter plates are separately breakapart, tests can be adapted to individual requirements
類型: Sandwich ELISA, Biotin-labelled antibody
別名:Myxovirus resistance protein 1
物種:Human
樣本濃度:10 μl/well
校準范圍:75–2500 pg/ml
檢測限:0.018 ng/ml
應用:Serum, Plasma
運輸:At ambient temperature. Upon receipt, store the product at the temperature recommended below.
儲存/到期:Store the complete kit at 2–8°C. Under these conditions, the kit is stable until the expiration date (see label on the box).
Biovendor是歐洲的一家生物醫藥科技公司,其科研及診斷產品事業部成立于1995年。Biovendor公司專注于研發與生產診斷及科研用途的免疫檢測試劑盒、抗體以及重組蛋白等產品。
產品覆蓋以下研究領域, 主要提供ELISA試劑盒,重組蛋白及相關抗體
凋亡(Apoptosis) |
糖尿病-胰島素、C-肽、胰島素原 (Diabetology - Insulin, C-Peptide, Proinsulin) |
肌生長調控 (Muscle Growth Control) |
自身免疫 (Autoimmunity) |
糖尿病-其他相關產品 (Diabetology - Other Relevant Products) |
神經組織標志物 (Neural Tissue Markers) |
血壓調節和NO代謝 (Blood Pressure Regulation And NO Metabolism) |
能量代謝和體重調節 (Energy Metabolism And Body Weight Regulation) |
腫瘤學 (Oncology) |
骨與軟骨代謝 (Bone And Cartilage Metabolism) |
生長hormone和生長因子相關 (Growth Hormone And Factor-related Products) |
氧化應激 (Oxidative Stress) |
心血管疾病 (Cardiovascular Disease) |
免疫應答、infect和炎癥反應 (Immune Response, Infection And Inflammation) |
胰調控分子 (Pancreatic Regulatory Molecules) |
細胞粘連蛋白 (Cell Adhesion Proteins) |
免疫學 (Immunology) |
腎臟疾病 (Renal Disease) |
細胞因子、趨化因子及相關分子 (Cytokines And Chemokines And Related Molecules) |
鐵代謝(Iron Metabolism) |
生殖 (Reproduction) |
糖尿病-自身免疫 (Diabetology – Autoimmunity) |
脂蛋白代謝 (Lipoprotein Metabolism) |
細胞表面蛋白 (Cell Surface Proteins (sCD) ) |
分泌型磷脂酶A2 (Secreted Phospholipases A2 show all) |
血清學 (Serology) |
類固醇hormone (Steroid Hormones) |
移植 (Transplantation) |
動物相關研究 (Animal Studies) |
其他研究領域 (Others) |
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